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18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Featured Image
  • 18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex
  • 18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex
  • 18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex

18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex

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18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Detail:

Product Detail

Name  N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
CAS number  14636-12-5
Molecular formula  C52H74N16O15S2
Molecular weight  1227.37
EINECS Number  238-680-8
Boiling point  1824.0±65.0 °C (Predicted)
Density  1.46±0.1 g/cm3(Predicted)
Storage conditions  Keep in dark place, Inert atmosphere, Store in freezer, under -15°C.
Acidity coefficient  (pKa) 9.90±0.15 (Predicted)

Synonyms

[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.

Description

Terlipressin, whose chemical name is triglycyllysine vasopressin, is a new synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. It is acted by aminopeptidase in vivo to slowly “release” the active lysine vasopressin after removing the three glycyl residues at its N-terminus. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.

The pharmacological effect of terlipressin is to contract splanchnic vascular smooth muscle and reduce splanchnic blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal blood flow and portal pressure. On the other hand, it can also reduce plasma The effect of renin concentration, thereby increasing renal blood flow, improving renal function and increasing urine output in patients with hepatorenal syndrome. Terlipressin is currently the only drug that can improve the survival rate of patients with esophageal variceal hemorrhage. It was mainly used in the clinical treatment of variceal hemorrhage. In addition, terlipressin has also been successfully used in the liver and kidney. In general, it is likely to play a beneficial role in coexisting refractory shock and cardiopulmonary resuscitation. Compared with vasopressin, it has a long-lasting effect, does not cause dangerous complications, including fibrinolysis and serious complications in the cardiovascular system, and is simple to use (intravenous injection), which is more suitable for acute and critical care. Rescue and treatment of critically ill patients.

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18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

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"Sincerity, Innovation, Rigorousness, and Efficiency" would be the persistent conception of our corporation to the long-term to establish collectively with customers for mutual reciprocity and mutual benefit for 18 Years Factory Trisodium Acetate - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex , The product will supply to all over the world, such as: New York, Finland, Israel, So We also continuously function. we, focuse on high quality, and are conscious of the importance of environmental protection, most of the merchandise are pollution-free, environmentally friendly solutions, reuse on the solution. We've Updated our catalog, which introduces our organization. n detail and covers the primary products we provide at present, You may also visit our web-site, which involves our most recent product line. We look forward to reactivating our company connection.
    • The company can think what our think, the urgency of urgency to act in the interests of our position, can be said this is a responsible company, we had a happy cooperation!
    5 Stars By Doris from Boston - 2017.03.28 12:22
    This company conforms to the market requirement and joins in the market competition by its high quality product, this is an enterprise that have Chinese spirit.
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