• head_banner_01

2022 Good Quality Low Sodium Low Chloride - Caspofungin for Antifungal Infections – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We always continually provide you with the most conscientious customer service, and the widest variety of designs and styles with finest materials. These efforts include the availability of customized designs with speed and dispatch for M1 Pseudouridine, Cas 557795-19-4 With Purity 99%, Salmeterol, We've been not pleased while using the present achievements but we are trying finest to innovate to satisfy buyer's much more personalized needs. No matter where you will be from, we have been here to wait for your sort ask for, and welcom to go to our manufacturing facility. Choose us, you can meet your trusted supplier.
2022 Good Quality Low Sodium Low Chloride - Caspofungin for Antifungal Infections – Gentolex Detail:

Product Detail

Name  Caspofungin
CAS number  162808-62-0
Molecular formula  C52H88N10O15
Molecular weight  1093.31
EINECS Number  1806241-263-5
Boiling point  1408.1±65.0 °C (Predicted)
Density  1.36±0.1 g/cm3(Predicted)
Acidity coefficient  (pKa) 9.86±0.26 (Predicted)

Synonyms

CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650

Chemical Properties

Caspofungin was the first echinocandin approved for the treatment of invasive fungal infections. In vitro and in vivo experiments confirmed that caspofungin has good antibacterial activity against important opportunistic pathogens-Candida and Aspergillus. Caspofungin can rupture the cell wall by inhibiting the synthesis of 1,3-β-glucan. Clinically, caspofungin has a good effect on the treatment of various candidiasis and aspergillosis.

Effect

(1,3)-D-glucan synthase is a key component of fungal cell wall synthesis, and caspofungin can exert an antifungal effect by non-competitively inhibiting this enzyme. After intravenous administration, the plasma drug concentration drops rapidly due to tissue distribution, followed by a gradual rerelease of the drug from the tissue. Metabolism of caspofungin increased with increasing dose and was dose-related in the time to steady state with multiple doses. Therefore, in order to achieve effective therapeutic levels and avoid drug accumulation, a first loading dose should be administered followed by a maintenance dose. When using cytochrome p4503A4 inducers at the same time, such as rifampicin, carbamazepine, dexamethasone, phenytoin, etc., it is recommended to increase the maintenance dose of caspofungin.

Indications

FDA-approved indications for caspofungin include: 1. Fever with neutropenia: defined as: fever >38°C with absolute neutrophil count (ANC) ≤500/ml, or with ANC ≤1000/ml and it is predicted that it can be reduced to below 500/ml. According to the recommendation of the Infectious Diseases Society of America (IDSA), although patients with persistent fever and neutropenia have been treated with broad-spectrum antibiotics, high-risk patients are still recommended to use empiric antifungal therapy, including caspofungin and other antifungal drugs. . 2. Invasive candidiasis: IDSA recommends echinocandins (such as caspofungin) as the drug of choice for candidemia. It can also be used to treat intra-abdominal abscesses, peritonitis and chest infections caused by Candida infection. 3. Esophageal candidiasis: Caspofungin can be used to treat esophageal candidiasis in patients with refractory or intolerance to other therapies. Several studies have found that the therapeutic effect of caspofungin is comparable to that of fluconazole. 4. Invasive aspergillosis: Caspofungin has been approved for the treatment of invasive aspergillosis in patients with intolerance, resistance, and ineffectiveness of the main antifungal drug, voriconazole. However, echinocandin is not recommended as first-line therapy.


Product detail pictures:

2022 Good Quality Low Sodium Low Chloride - Caspofungin for Antifungal Infections – Gentolex detail pictures

2022 Good Quality Low Sodium Low Chloride - Caspofungin for Antifungal Infections – Gentolex detail pictures


Related Product Guide:

Our eternal pursuits are the attitude of "regard the market, regard the custom, regard the science" as well as the theory of "quality the basic, believe in the 1st and management the advanced" for 2022 Good Quality Low Sodium Low Chloride - Caspofungin for Antifungal Infections – Gentolex , The product will supply to all over the world, such as: Mexico, Milan, Korea, Our company always concentrate on the development of the international market. We've got a lot of customers in Russia , European countries, the USA, the Middle East countries and Africa countries. We always follow that quality is foundation while service is guarantee to meet all customers.
  • We have been cooperated with this company for many years, the company always ensure timely delivery ,good quality and correct number, we are good partners.
    5 Stars By Mary from Philippines - 2017.12.02 14:11
    This manufacturers not only respected our choice and requirements, but also gave us a lot of good suggestions, ultimately, we successfully completed the procurement tasks.
    5 Stars By Nicole from Afghanistan - 2017.10.25 15:53
    Write your message here and send it to us