• head_banner_01

2022 Latest Design Diethyl Maleate - Ganirelix Acetate Peptide API – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

With a positive and progressive attitude to customer's interest, our enterprise continually improves our products excellent to meet the wants of customers and further focuses on safety, reliability, environmental requirements, and innovation of 3′-Methoxypropiophenone, Cas 2199-59-9 With Purity 99%, Ammonium Acetate, All prices depend upon the quantity of your respective order; the extra you purchase, the extra economical the rate is. We also offer fantastic OEM provider to numerous famous brands.
2022 Latest Design Diethyl Maleate - Ganirelix Acetate Peptide API – Gentolex Detail:

Product Detail

Name  Ganirelix Acetate
CAS number  123246-29-7
Molecular formula  C80H113ClN18O13
Molecular weight  1570.34

Synonyms

Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/

Description

Ganirelix is a synthetic decapeptide compound, and its acetate salt, Ganirelix acetate is a gonadotropin-releasing hormone (GnRH) receptor antagonist. The amino acid sequence is: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Mainly clinically, it is used in women undergoing assisted reproductive technology controlled ovarian stimulation programs to prevent premature luteinizing hormone peaks and to treat fertility disorders due to this cause. The drug has the characteristics of less adverse reactions, high pregnancy rate and short treatment period, and has obvious advantages compared with similar drugs in clinical practice.

Pharmacological Action

The pulsatile release of gonadotropin-releasing hormone (GnRH) stimulates the synthesis and secretion of LH and FSH. The frequency of LH pulses in the mid and late follicular phases is approximately 1 per hour. These pulses are reflected in transient rises in serum LH. During mid-menstrual period, the massive release of GnRH causes a surge of LH. The midmenstrual LH surge can trigger several physiological responses, including: ovulation, oocyte meiotic resumption, and corpus luteum formation. The formation of the corpus luteum causes serum progesterone levels to rise, while estradiol levels fall. Ganirelix acetate is a GnRH antagonist that competitively blocks GnRH receptors on pituitary gonadotrophs and subsequent transduction pathways. It produces a rapid, reversible inhibition of gonadotropin secretion. The inhibitory effect of ganirelix acetate on pituitary LH secretion was stronger than that on FSH. Ganirelix acetate failed to induce the first release of endogenous gonadotropins, consistent with antagonism. Complete recovery of pituitary LH and FSH levels occurred within 48 hours after ganirelix acetate was discontinued.


Product detail pictures:

2022 Latest Design Diethyl Maleate - Ganirelix Acetate Peptide API – Gentolex detail pictures

2022 Latest Design Diethyl Maleate - Ganirelix Acetate Peptide API – Gentolex detail pictures


Related Product Guide:

We are ready to share our knowledge of marketing worldwide and recommend you suitable products at most aggressive costs. So Profi Tools offer you finest benefit of money and we are ready to produce alongside one another with 2022 Latest Design Diethyl Maleate - Ganirelix Acetate Peptide API – Gentolex , The product will supply to all over the world, such as: Canada, Miami, UAE, On today, we've got customers from all over the world, including USA, Russia, Spain, Italy, Singapore, Malaysia, Thailand, Poland, Iran and Iraq. The mission of our company is to deliver the highest quality products with best price. We've been looking forward to doing business with you!
  • This supplier's raw material quality is stable and reliable, has always been in accordance with the requirements of our company to provide the goods that quality meet our requirements.
    5 Stars By Elizabeth from Mexico - 2017.08.15 12:36
    Speaking of this cooperation with the Chinese manufacturer, I just want to say"well dodne", we are very satisfied.
    5 Stars By Bruno Cabrera from United States - 2017.03.28 16:34
    Write your message here and send it to us