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China Manufacturer for Budesonide - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex

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China Manufacturer for Budesonide - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex Detail:

Product Detail

Name  Linaclotide
CAS number  851199-59-2
Molecular formula  C59H79N15O21S6
Molecular weight  1526.74

Synonyms

Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)

Description

Linaclotide, a synthetic peptide structure containing 14 amino acids, is related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate) Cyclase-C) agonist drugs for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

Chemical Properties

Linaclotide is a white to off-white amorphous powder; slightly soluble in water and aqueous sodium chloride solution (0.9%).

How it works

Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic and endocrine activity. Both linaclotide and its active metabolite can bind to the guanylate cyclase-C (GC-C) receptor on the luminal surface of the small intestinal epithelium. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. The result of GC-C activation is increased intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP can reduce the activity of pain nerve fibers and reduce visceral pain in model animals. Intracellular cGMP can increase the secretion of chloride and bicarbonate in the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which eventually leads to the increase of small intestinal fluid secretion and the speed of small intestinal transit.

FAQ

Do you guarantee safe and secure delivery of products?

Yes, we always use high quality export packaging. We also use specialized hazard packing for dangerous goods and validated cold storage shippers for temperature sensitive items. Specialist packaging and non-standard packing requirements may incur an additional charge.

How about the shipping fees?

The shipping cost depends on the way you choose to get the goods. Express is normally the quickest but also most expensive way. By sea freight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.


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China Manufacturer for Budesonide - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures

China Manufacturer for Budesonide - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures


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That has a sound business credit history, outstanding after-sales service and modern producing facilities, we have earned an superb popularity amid our buyers across the planet for China Manufacturer for Budesonide - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex , The product will supply to all over the world, such as: Kenya, Liberia, Netherlands, We offer the great variety of products in this field. Besides, customized orders are also available. What's more, you will enjoy our excellent services. In one word, your satisfaction is guaranteed. Welcome to visit our company! For more information, please come to our website.If any further inquiries, please feel free to contact us.
  • The factory workers have a good team spirit, so we received high quality products fast, in addition, the price is also appropriate, this is a very good and reliable Chinese manufacturers.
    5 Stars By Alva from Brazil - 2018.12.22 12:52
    The company has a good reputation in this industry, and finally it tured out that choose them is a good choice.
    5 Stars By Delia Pesina from Armenia - 2018.12.11 11:26
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