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China Supplier Aceto Acetate - Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 – Gentolex

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China Supplier Aceto Acetate - Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 – Gentolex Detail:

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CAS 204656-20-2 Molecular Formula C172H265N43O51  
Molecular Weight 3751.20 Appearance White
Storage Condition Light resistance, 2-8 degree Package Aluminum foil bag/vial
Purity ≥98% Transportation Cold Chain and cool storage delivery

Ingredients of Liraglutide

Application

Type 2 diabetes

Liraglutide improves control of blood glucose. It reduces meal-related hyperglycemia (for 24 hours after administration) by increasing insulin secretion (only) when required by increasing glucose levels, delaying gastric emptying, and suppressing prandial glucagon secretion.
It is suitable for patients whose blood sugar is still poorly controlled after the maximum tolerated dose of metformin or sulfonylureas alone. It is used in combination with metformin or sulfonylureas.
It acts in a glucose-dependent manner, meaning it will stimulate insulin secretion only when blood glucose levels are higher than normal, preventing “overshoot”. Consequently, it shows negligible risk of hypoglycemia.
It has the potential for inhibiting apoptosis and stimulating regeneration of beta cells (seen in animal studies).
It decreases appetite and inhibits body weight gain, as shown in a head-to-head study versus glimepiride.

Pharmacological Action

Liraglutide is a GLP-1 analog with 97% sequence homology to human GLP-1, which can bind to and activate the GLP-1 receptor. The GLP-1 receptor is the target of native GLP-1, an endogenous incretin hormone that promotes glucose concentration-dependent insulin secretion from pancreatic β cells. Unlike native GLP-1, the pharmacokinetic and pharmacodynamic profiles of liraglutide in humans are suitable for a once-daily dosing regimen. After subcutaneous injection, its mechanism of prolonged action includes: self-association that slows absorption; binding to albumin; Higher enzyme stability and thus longer plasma half-life.

The activity of liraglutide is mediated by its specific interaction with the GLP-1 receptor, resulting in an increase in cyclic adenosine monophosphate (cAMP). Liraglutide stimulates insulin secretion in a glucose concentration-dependent manner, while reducing excess glucagon secretion in a glucose concentration-dependent manner.

Therefore, when blood glucose rises, insulin secretion is stimulated, while glucagon secretion is inhibited. In contrast, liraglutide reduces insulin secretion during hypoglycemia without affecting glucagon secretion. The hypoglycemic mechanism of liraglutide also includes a slight prolongation of gastric emptying time. Liraglutide reduces body weight and body fat mass by reducing hunger and energy intake.


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abide by the contract", conforms on the market requirement, joins from the market competition by its good quality likewise as provides more comprehensive and superb support for customers to let them become large winner. The pursue of the company, is definitely the clients' pleasure for China Supplier Aceto Acetate - Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 – Gentolex , The product will supply to all over the world, such as: Swedish, Slovak Republic, Argentina, To get more information about us as well as see all our products, please visit our website. To get more information please feel free to let us know. Thank you very much and wish your business always be great!
  • The supplier abide the theory of "quality the basic, trust the first and management the advanced" so that they can ensure a reliable product quality and stable customers.
    5 Stars By Sandra from The Swiss - 2017.09.30 16:36
    This is a reputable company, they have a high level of business management, good quality product and service, every cooperation is assured and delighted!
    5 Stars By Hannah from Roman - 2017.05.21 12:31
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