Name | Cetrorelix acetate |
CAS number | 120287-85-6 |
Molecular formula | C70H92ClN17O14 |
Molecular weight | 1431.04 |
EINECS Number | 686-384-6 |
AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH;Cetrorelixacetate;CETRORELIX;CETRORELIXACID;CETRIZINEDIHYDROCHLORIDE;ChemicalbookN-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2;Cetrorelixum;Cetrorelixum.
Cetrorelix acetate is a synthetic decapeptide, which is mainly used in assisted reproductive technology to prevent premature ovulation in patients with controlled ovarian stimulation. It is a gonadotropin-releasing hormone (GnRH) antagonist that can compete with endogenous LHRH to bind to receptors on the pituitary cell membrane, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by the pituitary in a dose-dependent manner.
Cetrorelix acetate is a gonadotropin-releasing hormone (GnRH) antagonist. This product competes with endogenous GnRH for receptors on pituitary cells, thereby inhibiting the release of endogenous luteinizing hormone (LH) and follicle-stimulating hormone (FSH), delaying the appearance of the LH peak, thereby controlling ovulation. The effect of this product is dose-dependent, the inhibitory effect is direct, and is maintained by continuous treatment, without causing an initial increase in progesterone receptor activity followed by a decrease.
Electric thermostatic stainless steel water bath
Box type resistance furnace
Electric heating constant temperature drying oven
Heated Incubators
Insoluble particle analyzer
Liquid chromatography
Automatic polarimeter
infrared spectrometer
UV / Visible photometer
Electric heating vacuum drying box
Vertical pressure steamer sterilizer
PH meter
Clarity Tester
Osmolality tester
Cassette Moisture Analyzer
Multi-parameter analyzer
Electric blast drying box
Biochemical incubator
Mold incubator
Aseptic isolator
Total organic carbon detector
Desktop Vacuum Dryer
Comprehensive drug stability test chamber
Constant temperature sink and water bath
Medical refrigerated storage box
Gas Chromatograph
Biological safety cabinet
Clean bench
TOC and conductivity of main supply and return points are monitored periodically. TOC is monitored by QC on every week. Conductivity is monitored online and recorded by purified water station operator once every four hours. The conductivity is monitored at the primary RO, secondary RO, EDI and total return point of distribution system. The specification of purified water is in place and conforms to pre-defined specification which no more than 1.3 µs/cm at 25°C (USP). For main supply and return points, full test. is performed every week, for other using point in the circulating loop, full test is performed once every month. The full test includes characters, pH, nitrate, nitrite, ammonia, conductivity, TOC, non-volatile substances, heavy metals, microbial limits and bacterial endotoxin.