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Deflazacort has anti-inflammatory, anti-allergic, and increased gluconeogenesis effects

Short Description:

Melting point: 255-256.5°C

Specific rotation: D+62.3°(c=0.5inchloroform)

Boiling point: 595.4±50.0°C (Predicted)

Density: 1.41

Storage conditions: 2-8°C

Solubility: DMSO: ≥20mg/mL

Acidity coefficient: (pKa) 14.30±0.70 (Predicted)

Form: powder

color: black


Product Detail

Product Tags

Product Detail

Name  Deflazacort
CAS number  14484-47-0
Molecular formula  C25H31NO6
Molecular weight  441.52
EINECS Number  238-483-7
Boiling point 595.4±50.0°C
Purity  98%
Storage  Sealed in dry,Room Temperature
Form  Powder
Color  White  
Packing  PE bag+Aluminum bag

Synonyms

16-d)oxazole-3,20-dione,11-beta,21-dihydroxy-2’-5’-beta-h-pregna-4-dieno(17;azacort;calcort;deflan;(5'β)-11β-Hydroxy-21-acetyloxy-2'-methyl-1,2,4,5-tetradehydropregnano[17,16-d]oxazole-3,20-dione;(5'β)-21-Acetyloxy-11β-hydroxy-2'-methylpregnano[17,16-d]oxazole-1,4-diene-3,20-dione;11b,21-Dihydroxy-2'-;Denazacort

Pharmacological Effect

Indications
For primary or secondary adrenal insufficiency, rheumatism, collagen disease, hematopoietic system disease, ulcerative colitis, idiopathic nephrotic syndrome, hematopoietic malignancies, allergic and allergic diseases, and in conjunction with Anti-tuberculosis drugs for the treatment of fulminant and disseminated pulmonary tuberculosis.

Precautions
(1) Like other glucocorticoids, it is contraindicated for systemic infectious diseases.
(2) Use with caution in diverticulitis, recent gastrointestinal surgery, renal failure, hypertension, diabetes, osteoporosis, myasthenia gravis and other diseases. Pregnant and lactating women use with caution.

Medicine Interactions
1. Deflazacort has a unique potassium excretion effect, so care should be taken when it is used in combination with diuretics.
2. When used in combination with drugs with enzymatic action (rifampicin, phenobarbital, etc.), glucocorticoids should be increased appropriately.
3. Erythromycin and estrogen can inhibit the metabolism of this product and active substances, and the dosage should be reduced when used together. Chemical properties Acetone-hexane crystallization, melting point 255-256.5 ℃. [α] D+62.3° (C=0.5, chloroform).

Usage
The third-generation glucocorticoids have anti-inflammatory, anti-allergic, and increased gluconeogenesis effects. For primary and secondary adrenal insufficiency, rheumatism, collagen disease, skin disease, allergic disease, eye disease, fulminant and disseminated tuberculosis, hematopoietic system disease, ulcerative colitis, idiopathic Nephrotic syndrome, hematopoietic malignancies, etc.


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