Name | Deflazacort |
CAS number | 14484-47-0 |
Molecular formula | C25H31NO6 |
Molecular weight | 441.52 |
EINECS Number | 238-483-7 |
Boiling point | 595.4±50.0°C |
Purity | 98% |
Storage | Sealed in dry,Room Temperature |
Form | Powder |
Color | White |
Packing | PE bag+Aluminum bag |
16-d)oxazole-3,20-dione,11-beta,21-dihydroxy-2’-5’-beta-h-pregna-4-dieno(17;azacort;calcort;deflan;(5'β)-11β-Hydroxy-21-acetyloxy-2'-methyl-1,2,4,5-tetradehydropregnano[17,16-d]oxazole-3,20-dione;(5'β)-21-Acetyloxy-11β-hydroxy-2'-methylpregnano[17,16-d]oxazole-1,4-diene-3,20-dione;11b,21-Dihydroxy-2'-;Denazacort
Indications
For primary or secondary adrenal insufficiency, rheumatism, collagen disease, hematopoietic system disease, ulcerative colitis, idiopathic nephrotic syndrome, hematopoietic malignancies, allergic and allergic diseases, and in conjunction with Anti-tuberculosis drugs for the treatment of fulminant and disseminated pulmonary tuberculosis.
Precautions
(1) Like other glucocorticoids, it is contraindicated for systemic infectious diseases.
(2) Use with caution in diverticulitis, recent gastrointestinal surgery, renal failure, hypertension, diabetes, osteoporosis, myasthenia gravis and other diseases. Pregnant and lactating women use with caution.
Medicine Interactions
1. Deflazacort has a unique potassium excretion effect, so care should be taken when it is used in combination with diuretics.
2. When used in combination with drugs with enzymatic action (rifampicin, phenobarbital, etc.), glucocorticoids should be increased appropriately.
3. Erythromycin and estrogen can inhibit the metabolism of this product and active substances, and the dosage should be reduced when used together. Chemical properties Acetone-hexane crystallization, melting point 255-256.5 ℃. [α] D+62.3° (C=0.5, chloroform).
Usage
The third-generation glucocorticoids have anti-inflammatory, anti-allergic, and increased gluconeogenesis effects. For primary and secondary adrenal insufficiency, rheumatism, collagen disease, skin disease, allergic disease, eye disease, fulminant and disseminated tuberculosis, hematopoietic system disease, ulcerative colitis, idiopathic Nephrotic syndrome, hematopoietic malignancies, etc.