Estradiol Cypionate

Studies

Estradiolcypionate is a natural estrogen, a synthetic ester of estradiol. By intramuscular injection, estradiol cypionate was found to have the longest duration of action of 11 days compared to other commonly used estradiol esters, while estradiol benzoate and estradiol valerate The duration of action is 4-5 days and 7-8 days, respectively.

Estradiolcypionate has several uses in bovine medicine. Included in the treatment of follicular cysts lack of libido, persistent corpus luteum, pyometra, and retained placenta. Possibly, ECP is beneficial for high-risk postpartum diseases by stimulating uterine contractions directly or maintaining oxytocin receptor sites in the uterus, promoting more WBCs to infection sites by increasing uterine blood flow, enhancing uterine immune function, and increasing bacterial phagocytosis effect, or the movement of IgA and IgG to the uterine cavity, or promote uterine drainage by delaying cervical closure.

Description

Estradiol cypionate (o)estradiolcypionateC26H36O3 is a sex hormone. There are two types of α and β, and the α type has a strong physiological effect. Wintersteiner et al. (Wintersteiner et al. 1935) have extracted it from pregnant horse urine, and can also be obtained from pregnant woman urine, human placenta, pig ovary, etc. It is also present in the testes or urine of stallions. Because of its strong sex hormone action, it is thought that it or its esters are actually the most important sex hormones secreted by the ovaries. The benzoate ester of estradiol cypionate is adopted as one of the reference substances in International Units that determine the potency of sex hormones. Estradiol cypionate is a kind of estrogen, which can promote and regulate the normal development of female sexual organs and secondary sexual characteristics. It can promote the development and hyperplasia of breast ducts, but when the dose is large, it can inhibit the release of prolactin in the anterior pituitary gland and reduce milk secretion.

Clinical application

The common ones are nausea, vomiting, dizziness, increased leucorrhea, etc. Taking it after meals or reducing the dose can relieve the symptoms, and most of the above-mentioned adverse reactions will subside after continuing to take the medicine. Prolonged use can cause hyperplasia of the endometrium or bleeding. Long-term large-scale application can cause edema due to water and sodium retention. Use with caution in patients with hepatic and renal insufficiency