• head_banner_01

Excellent quality Tenofovir Alafenamide Fumarate - Ganirelix Acetate Peptide API – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

"Based on domestic market and expand overseas business" is our development strategy for Cardio-Cerebral Vascular System, Thioglycolate De Sodium, Vancomycin, We sincerely expect exchange and cooperation with you. Let us move forward hand in hand and achieve win-win situation.
Excellent quality Tenofovir Alafenamide Fumarate - Ganirelix Acetate Peptide API – Gentolex Detail:

Product Detail

Name  Ganirelix Acetate
CAS number  123246-29-7
Molecular formula  C80H113ClN18O13
Molecular weight  1570.34

Synonyms

Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/

Description

Ganirelix is a synthetic decapeptide compound, and its acetate salt, Ganirelix acetate is a gonadotropin-releasing hormone (GnRH) receptor antagonist. The amino acid sequence is: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Mainly clinically, it is used in women undergoing assisted reproductive technology controlled ovarian stimulation programs to prevent premature luteinizing hormone peaks and to treat fertility disorders due to this cause. The drug has the characteristics of less adverse reactions, high pregnancy rate and short treatment period, and has obvious advantages compared with similar drugs in clinical practice.

Pharmacological Action

The pulsatile release of gonadotropin-releasing hormone (GnRH) stimulates the synthesis and secretion of LH and FSH. The frequency of LH pulses in the mid and late follicular phases is approximately 1 per hour. These pulses are reflected in transient rises in serum LH. During mid-menstrual period, the massive release of GnRH causes a surge of LH. The midmenstrual LH surge can trigger several physiological responses, including: ovulation, oocyte meiotic resumption, and corpus luteum formation. The formation of the corpus luteum causes serum progesterone levels to rise, while estradiol levels fall. Ganirelix acetate is a GnRH antagonist that competitively blocks GnRH receptors on pituitary gonadotrophs and subsequent transduction pathways. It produces a rapid, reversible inhibition of gonadotropin secretion. The inhibitory effect of ganirelix acetate on pituitary LH secretion was stronger than that on FSH. Ganirelix acetate failed to induce the first release of endogenous gonadotropins, consistent with antagonism. Complete recovery of pituitary LH and FSH levels occurred within 48 hours after ganirelix acetate was discontinued.


Product detail pictures:

Excellent quality Tenofovir Alafenamide Fumarate - Ganirelix Acetate Peptide API – Gentolex detail pictures

Excellent quality Tenofovir Alafenamide Fumarate - Ganirelix Acetate Peptide API – Gentolex detail pictures


Related Product Guide:

Gaining customer satisfaction is our company's aim forever. We will make great efforts to develop new and top-quality products, meet your special requirements and provide you with pre-sale, on-sale and after-sale services for Excellent quality Tenofovir Alafenamide Fumarate - Ganirelix Acetate Peptide API – Gentolex , The product will supply to all over the world, such as: Malawi, Afghanistan, Mauritius, Our company abides by the management idea of "keep innovation, pursue excellence". On the basis of assuring the advantages of existing products, we continuously strengthen and extend product development. Our company insists on innovation to promote the sustainable development of enterprise, and make us become the domestic high-quality suppliers.
  • Products and services are very good, our leader is very satisfied with this procurement, it is better than we expected,
    5 Stars By John from Ecuador - 2018.09.12 17:18
    The factory workers have a good team spirit, so we received high quality products fast, in addition, the price is also appropriate, this is a very good and reliable Chinese manufacturers.
    5 Stars By Page from Congo - 2017.12.19 11:10
    Write your message here and send it to us