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Factory best selling Gamma Amino Acid - Caspofungin for Antifungal Infections – Gentolex

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Factory best selling Gamma Amino Acid - Caspofungin for Antifungal Infections – Gentolex Detail:

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Name  Caspofungin
CAS number  162808-62-0
Molecular formula  C52H88N10O15
Molecular weight  1093.31
EINECS Number  1806241-263-5
Boiling point  1408.1±65.0 °C (Predicted)
Density  1.36±0.1 g/cm3(Predicted)
Acidity coefficient  (pKa) 9.86±0.26 (Predicted)

Synonyms

CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650

Chemical Properties

Caspofungin was the first echinocandin approved for the treatment of invasive fungal infections. In vitro and in vivo experiments confirmed that caspofungin has good antibacterial activity against important opportunistic pathogens-Candida and Aspergillus. Caspofungin can rupture the cell wall by inhibiting the synthesis of 1,3-β-glucan. Clinically, caspofungin has a good effect on the treatment of various candidiasis and aspergillosis.

Effect

(1,3)-D-glucan synthase is a key component of fungal cell wall synthesis, and caspofungin can exert an antifungal effect by non-competitively inhibiting this enzyme. After intravenous administration, the plasma drug concentration drops rapidly due to tissue distribution, followed by a gradual rerelease of the drug from the tissue. Metabolism of caspofungin increased with increasing dose and was dose-related in the time to steady state with multiple doses. Therefore, in order to achieve effective therapeutic levels and avoid drug accumulation, a first loading dose should be administered followed by a maintenance dose. When using cytochrome p4503A4 inducers at the same time, such as rifampicin, carbamazepine, dexamethasone, phenytoin, etc., it is recommended to increase the maintenance dose of caspofungin.

Indications

FDA-approved indications for caspofungin include: 1. Fever with neutropenia: defined as: fever >38°C with absolute neutrophil count (ANC) ≤500/ml, or with ANC ≤1000/ml and it is predicted that it can be reduced to below 500/ml. According to the recommendation of the Infectious Diseases Society of America (IDSA), although patients with persistent fever and neutropenia have been treated with broad-spectrum antibiotics, high-risk patients are still recommended to use empiric antifungal therapy, including caspofungin and other antifungal drugs. . 2. Invasive candidiasis: IDSA recommends echinocandins (such as caspofungin) as the drug of choice for candidemia. It can also be used to treat intra-abdominal abscesses, peritonitis and chest infections caused by Candida infection. 3. Esophageal candidiasis: Caspofungin can be used to treat esophageal candidiasis in patients with refractory or intolerance to other therapies. Several studies have found that the therapeutic effect of caspofungin is comparable to that of fluconazole. 4. Invasive aspergillosis: Caspofungin has been approved for the treatment of invasive aspergillosis in patients with intolerance, resistance, and ineffectiveness of the main antifungal drug, voriconazole. However, echinocandin is not recommended as first-line therapy.


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Factory best selling Gamma Amino Acid - Caspofungin for Antifungal Infections – Gentolex detail pictures

Factory best selling Gamma Amino Acid - Caspofungin for Antifungal Infections – Gentolex detail pictures


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"Sincerity, Innovation, Rigorousness, and Efficiency" is the persistent conception of our firm for the long-term to create jointly with consumers for mutual reciprocity and mutual reward for Factory best selling Gamma Amino Acid - Caspofungin for Antifungal Infections – Gentolex , The product will supply to all over the world, such as: Greek, South Africa, Birmingham, In order to meet our market demands, we have paied more attention to the quality of our products and services. Now we can meet customers' special requirements for special designs. We persistently develop our enterprise spirit "quality lives the enterprise, credit assures cooperation and keep the motto in our minds: customers first.
  • As an international trading company, we have numerous partners, but about your company, I just want to say, you are really good, wide range, good quality, reasonable prices, warm and thoughtful service, advanced technology and equipment and workers have professional training, feedback and product update is timely, in short, this is a very pleasant cooperation, and we look forward to the next cooperation!
    5 Stars By Maud from Canberra - 2018.05.15 10:52
    A good manufacturers, we have cooperated twice, good quality and good service attitude.
    5 Stars By Anna from Myanmar - 2017.09.16 13:44
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