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Factory best selling Vancomycin Resistant - Ganirelix Acetate Peptide API – Gentolex

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Factory best selling Vancomycin Resistant - Ganirelix Acetate Peptide API – Gentolex Detail:

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Name  Ganirelix Acetate
CAS number  123246-29-7
Molecular formula  C80H113ClN18O13
Molecular weight  1570.34

Synonyms

Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/

Description

Ganirelix is a synthetic decapeptide compound, and its acetate salt, Ganirelix acetate is a gonadotropin-releasing hormone (GnRH) receptor antagonist. The amino acid sequence is: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Mainly clinically, it is used in women undergoing assisted reproductive technology controlled ovarian stimulation programs to prevent premature luteinizing hormone peaks and to treat fertility disorders due to this cause. The drug has the characteristics of less adverse reactions, high pregnancy rate and short treatment period, and has obvious advantages compared with similar drugs in clinical practice.

Pharmacological Action

The pulsatile release of gonadotropin-releasing hormone (GnRH) stimulates the synthesis and secretion of LH and FSH. The frequency of LH pulses in the mid and late follicular phases is approximately 1 per hour. These pulses are reflected in transient rises in serum LH. During mid-menstrual period, the massive release of GnRH causes a surge of LH. The midmenstrual LH surge can trigger several physiological responses, including: ovulation, oocyte meiotic resumption, and corpus luteum formation. The formation of the corpus luteum causes serum progesterone levels to rise, while estradiol levels fall. Ganirelix acetate is a GnRH antagonist that competitively blocks GnRH receptors on pituitary gonadotrophs and subsequent transduction pathways. It produces a rapid, reversible inhibition of gonadotropin secretion. The inhibitory effect of ganirelix acetate on pituitary LH secretion was stronger than that on FSH. Ganirelix acetate failed to induce the first release of endogenous gonadotropins, consistent with antagonism. Complete recovery of pituitary LH and FSH levels occurred within 48 hours after ganirelix acetate was discontinued.


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Factory best selling Vancomycin Resistant - Ganirelix Acetate Peptide API – Gentolex detail pictures

Factory best selling Vancomycin Resistant - Ganirelix Acetate Peptide API – Gentolex detail pictures


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Dependable good quality and very good credit score standing are our principles, which will help us at a top-ranking position. Adhering towards the tenet of "quality initial, shopper supreme" for Factory best selling Vancomycin Resistant - Ganirelix Acetate Peptide API – Gentolex , The product will supply to all over the world, such as: Moldova, Chile, Liberia, The best and original quality for spare parts is a most important factor for transportation. We may stick on supplying original and good quality parts even a little profit earned. God will bless us to do kindness business forever.
  • The factory has advanced equipment, experienced staffs and good management level, so product quality had assurance, this cooperation is very relaxed and happy!
    5 Stars By Moira from UK - 2017.09.16 13:44
    Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
    5 Stars By Meredith from Denmark - 2017.01.28 19:59
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