• head_banner_01

Factory For Nafcillin Sodium - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We've been convinced that with joint efforts, the enterprise between us will bring us mutual benefits. We are able to assure you product or service quality and aggressive cost for Organic Intermediate, Sodium Pyrithione_Spt 3811-73-2, Hexenyl Acetate, We are sincerely looking forward to establishing good cooperative relationships with customers from at home and abroad for creating a bright future together.
Factory For Nafcillin Sodium - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex Detail:

Product Detail

Name  Linaclotide
CAS number  851199-59-2
Molecular formula  C59H79N15O21S6
Molecular weight  1526.74

Synonyms

Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)

Description

Linaclotide, a synthetic peptide structure containing 14 amino acids, is related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate) Cyclase-C) agonist drugs for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

Chemical Properties

Linaclotide is a white to off-white amorphous powder; slightly soluble in water and aqueous sodium chloride solution (0.9%).

How it works

Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic and endocrine activity. Both linaclotide and its active metabolite can bind to the guanylate cyclase-C (GC-C) receptor on the luminal surface of the small intestinal epithelium. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. The result of GC-C activation is increased intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP can reduce the activity of pain nerve fibers and reduce visceral pain in model animals. Intracellular cGMP can increase the secretion of chloride and bicarbonate in the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which eventually leads to the increase of small intestinal fluid secretion and the speed of small intestinal transit.

FAQ

Do you guarantee safe and secure delivery of products?

Yes, we always use high quality export packaging. We also use specialized hazard packing for dangerous goods and validated cold storage shippers for temperature sensitive items. Specialist packaging and non-standard packing requirements may incur an additional charge.

How about the shipping fees?

The shipping cost depends on the way you choose to get the goods. Express is normally the quickest but also most expensive way. By sea freight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.


Product detail pictures:

Factory For Nafcillin Sodium - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures

Factory For Nafcillin Sodium - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures


Related Product Guide:

We offer wonderful energy in high-quality and improvement,merchandising,product sales and marketing and advertising and procedure for Factory For Nafcillin Sodium - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex , The product will supply to all over the world, such as: Slovenia, Brunei, Miami, With the aim of "compete with good quality and develop with creativity" and the service principle of "take customers' demand as orientation", we will earnestly provide qualified products and solutions and good service for domestic and international customers.
  • The company account manager has a wealth of industry knowledge and experience, he could provide appropriate program according our needs and speak English fluently.
    5 Stars By Gloria from Comoros - 2018.06.05 13:10
    Customer service staff and sales man are very patience and they all good at English, product's arrival is also very timely, a good supplier.
    5 Stars By Linda from Birmingham - 2018.07.26 16:51
    Write your message here and send it to us