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factory low price Dispensable Amino Acids - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex

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We believe in: Innovation is our soul and spirit. High-quality is our life. Consumer need to have is our God for 3 3-Dimethyl-1-Butyne, Isonicotinic Acid, Leuprorelin, We are looking forwards to establishing long-term business relationships with worldwide customers.
factory low price Dispensable Amino Acids - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex Detail:

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Name  Leuprorelin
CAS number  53714-56-0
Molecular formula  C59H84N16O12
Molecular weight  1209.4
EINECS Number  633-395-9
Specific rotation  D25 -31.7° (c = 1 in 1% acetic acid)
Density  1.44±0.1 g/cm3(Predicted)
Storage condition  -15°C
Form  Neat
Acidity coefficient  (pKa) 9.82±0.15 (Predicted)
Water solubility  Soluble in water at 1mg/ml

Synonyms

LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGHORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(HUMAN)

Pharmacological Effect

Leuprolide, goserelin, triprelin, and nafarelin are several drugs commonly used in clinical practice to remove ovaries for the treatment of premenopausal breast cancer and prostate cancer. (referred to as GnRH-a drugs), GnRH-a drugs are similar in structure to GnRH and compete with pituitary GnRH receptors. That is, the gonadotropin secreted by the pituitary decreases, which leads to a significant decrease in the sex hormone secreted by the ovary.

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog, a peptide composed of 9 amino acids. This product can effectively inhibit the function of the pituitary-gonadal system, the resistance to proteolytic enzymes and the affinity to the pituitary GnRH receptor are stronger than GnRH, and the activity of promoting the release of luteinizing hormone (LH) is about 20 times that of GnRH. It also has a stronger inhibitory effect on pituitary-gonad function than GnRH. In the initial stage of treatment, follicle stimulating hormone (FSH), LH, estrogen or androgen may be temporarily increased, and then, due to the decreased responsiveness of the pituitary gland, the secretion of FSH, LH and estrogen or androgen is inhibited, resulting in dependence on sex hormones. Sexual diseases (such as prostate cancer, endometriosis, etc.) have a therapeutic effect.

At present, the acetate salt of leuprolide is mainly used clinically, because the performance of leuprolide acetate is more stable at room temperature. Liquid should be discarded. It can be used for the drug castration treatment of endometriosis and uterine fibroids, central precocious puberty, premenopausal breast cancer and prostate cancer, and also for functional uterine bleeding that is contraindicated or ineffective for conventional hormone therapy. It can also be used as a premedication before endometrial resection, which can evenly thin the endometrium, reduce edema, and reduce the difficulty of surgery.


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factory low price Dispensable Amino Acids - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex detail pictures

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With our leading technology also as our spirit of innovation,mutual cooperation, benefits and development, we are going to build a prosperous future jointly with your esteemed company for factory low price Dispensable Amino Acids - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex , The product will supply to all over the world, such as: Bhutan, Czech, Congo, We would very much welcome an opportunity to do business with you and have pleasure in attaching further details of our products. Excellent quality, competitive prices,punctual delivery and dependable service can be guaranteed.
  • The manufacturer gave us a big discount under the premise of ensuring the quality of products, thank you very much, we will select this company again.
    5 Stars By Andrew from Tajikistan - 2018.02.12 14:52
    Production management mechanism is completed, quality is guaranteed, high credibility and service let the cooperation is easy, perfect!
    5 Stars By Julie from Sevilla - 2017.09.16 13:44
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