• head_banner_01

factory Outlets for Piperidinium Acetate - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We are also specializing in improving the things management and QC method in order that we could retain terrific edge inside the fiercely-competitive small business for Choline Acetate, Hypertonic Sodium Chloride, Glp-1 Protected Amino Acid, How about to start your good business with our company? We are ready, trained and fulfilled with pride. Let’s start our new business with new wave.
factory Outlets for Piperidinium Acetate - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex Detail:

Product Detail

Name  CARBETOCIN
CAS number  37025-55-1
Molecular formula  C45H69N11O12S
Molecular weight  988.17
EINECS Number  253-312-6
Specific rotation  D -69.0° (c = 0.25 in 1M acetic acid)
Boiling point  1477.9±65.0 °C (Predicted)
Density  1.218±0.06 g/cm3(Predicted)
Storage conditions  -15°C
Form  powder

Synonyms

BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN

Biological activity

Carbetocin, an oxytocin (OT) analog, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has a high affinity (Ki=1.17 μM) for the chimeric N-terminus of the oxytocin receptor. Carbetocin has potential for postpartum hemorrhage research. Carbetocin can penetrate the blood-brain barrier and has antidepressant-like activity by activating oxytocin receptors in the CNS.

Function

Carbetocin is a synthetic long-acting oxytocin 8-peptide analog with agonist properties, and its clinical and pharmacological properties are similar to those of naturally occurring oxytocin. Like oxytocin, carbetocin binds to the hormone receptors of uterine smooth muscle, causing rhythmic contractions of the uterus, increasing its frequency and increasing uterine tone on the basis of the contractions of the original. Oxytocin receptor levels in the uterus are low in the non-pregnant state, increase during pregnancy, and peak during labor. Therefore, carbetocin has no effect on the non-pregnant uterus, but has a potent uterine contractile effect on the pregnant uterus and the newly produced uterus.

Change Controls

Changes are controlled according to the procedure. Based on the impact and risk and severity, changes are classified as Major, Minor and Site. Site changes have slight impact on safety and quality of product, and therefore do not need approval and notification to the customer; Minor changes have moderate impact on safety and quality of product, and need to notify the customer; Major changes have higher impact on safety and quality of product, and need approval by the customer.

According to the procedure, change control is started with change application in which change details and rational for the change are described. The evaluation is then performed following the application, which is done by change control relevant departments. Meanwhile, the change control is classified into Major level, General level and Minor level. After appropriate evaluation as well as the classification, all level change control should be approved by QA Manager. The change control is executed after approval according to the action plan. The change control is finally closed after QA confirms the change control has been appropriately implemented. If involving client notification, the client should be notified timely after change control approved


Product detail pictures:

factory Outlets for Piperidinium Acetate - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage  – Gentolex detail pictures


Related Product Guide:

Adhering to your principle of "quality, assistance, performance and growth", we have now gained trusts and praises from domestic and international customer for factory Outlets for Piperidinium Acetate - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex , The product will supply to all over the world, such as: venezuela, Maldives, Rio de Janeiro, Our products are widely recognized and trusted by users and can meet continuously developing economic and social needs. We welcome new and old customers from all walks of life to contact us for future business relationships and achieving mutual success!
  • Perfect services, quality products and competitive prices, we have work many times, every time is delighted, wish continue to maintain!
    5 Stars By Lee from Argentina - 2017.12.09 14:01
    Cooperate with you every time is very successful, very happy. Hope that we can have more cooperation!
    5 Stars By Mary from Gabon - 2017.11.01 17:04
    Write your message here and send it to us