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Factory Price 2,6-Dihydroxy-3-Cyano-4-Methyl Pyridine - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex

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We are also focusing on improving the stuff management and QC system so that we could keep great advantage in the fiercely-competitive business for Empagliflozin, 4-Hydroxypyridine, Vanillin Acetate, The main goal of our company would be to live a satisfactory memory to all of the shoppers, and establish a long term company romantic relationship with customers and users all around the entire world.
Factory Price 2,6-Dihydroxy-3-Cyano-4-Methyl Pyridine - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex Detail:

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Name  Linaclotide
CAS number  851199-59-2
Molecular formula  C59H79N15O21S6
Molecular weight  1526.74

Synonyms

Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)

Description

Linaclotide, a synthetic peptide structure containing 14 amino acids, is related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate) Cyclase-C) agonist drugs for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

Chemical Properties

Linaclotide is a white to off-white amorphous powder; slightly soluble in water and aqueous sodium chloride solution (0.9%).

How it works

Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic and endocrine activity. Both linaclotide and its active metabolite can bind to the guanylate cyclase-C (GC-C) receptor on the luminal surface of the small intestinal epithelium. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. The result of GC-C activation is increased intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP can reduce the activity of pain nerve fibers and reduce visceral pain in model animals. Intracellular cGMP can increase the secretion of chloride and bicarbonate in the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which eventually leads to the increase of small intestinal fluid secretion and the speed of small intestinal transit.

FAQ

Do you guarantee safe and secure delivery of products?

Yes, we always use high quality export packaging. We also use specialized hazard packing for dangerous goods and validated cold storage shippers for temperature sensitive items. Specialist packaging and non-standard packing requirements may incur an additional charge.

How about the shipping fees?

The shipping cost depends on the way you choose to get the goods. Express is normally the quickest but also most expensive way. By sea freight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.


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Factory Price 2,6-Dihydroxy-3-Cyano-4-Methyl Pyridine - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures

Factory Price 2,6-Dihydroxy-3-Cyano-4-Methyl Pyridine - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures


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We now have many fantastic staff members customers superior at advertising, QC, and working with varieties of troublesome problem within the generation system for Factory Price 2,6-Dihydroxy-3-Cyano-4-Methyl Pyridine - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex , The product will supply to all over the world, such as: Portugal, Mecca, Doha, We now have established long-term, stable and good business relationships with many manufacturers and wholesalers around the world. Currently, we've been looking forward to even greater cooperation with overseas customers based on mutual benefits. You should feel free to contact us for more details.
  • Staff is skilled, well-equipped, process is specification, products meet the requirements and delivery is guaranteed, a best partner!
    5 Stars By Dominic from Mexico - 2018.09.12 17:18
    This enterprise in the industry is strong and competitive, advancing with the times and develop sustainable, we are very pleased to have a opportunity to cooperate!
    5 Stars By Kelly from Southampton - 2017.08.18 11:04
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