• head_banner_01

Factory Price For Octreotide - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

With our rich experience and considerate services, we have been recognized as a reliable supplier for many international buyers for 1-(4-Methoxyphenyl)Methanamine, China 439081-18-2, Organic Intermediate, Items won certifications with the regional and international primary authorities. For far more detailed information, please contact us!
Factory Price For Octreotide - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex Detail:

Product Detail

Name  Leuprorelin
CAS number  53714-56-0
Molecular formula  C59H84N16O12
Molecular weight  1209.4
EINECS Number  633-395-9
Specific rotation  D25 -31.7° (c = 1 in 1% acetic acid)
Density  1.44±0.1 g/cm3(Predicted)
Storage condition  -15°C
Form  Neat
Acidity coefficient  (pKa) 9.82±0.15 (Predicted)
Water solubility  Soluble in water at 1mg/ml

Synonyms

LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGHORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(HUMAN)

Pharmacological Effect

Leuprolide, goserelin, triprelin, and nafarelin are several drugs commonly used in clinical practice to remove ovaries for the treatment of premenopausal breast cancer and prostate cancer. (referred to as GnRH-a drugs), GnRH-a drugs are similar in structure to GnRH and compete with pituitary GnRH receptors. That is, the gonadotropin secreted by the pituitary decreases, which leads to a significant decrease in the sex hormone secreted by the ovary.

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog, a peptide composed of 9 amino acids. This product can effectively inhibit the function of the pituitary-gonadal system, the resistance to proteolytic enzymes and the affinity to the pituitary GnRH receptor are stronger than GnRH, and the activity of promoting the release of luteinizing hormone (LH) is about 20 times that of GnRH. It also has a stronger inhibitory effect on pituitary-gonad function than GnRH. In the initial stage of treatment, follicle stimulating hormone (FSH), LH, estrogen or androgen may be temporarily increased, and then, due to the decreased responsiveness of the pituitary gland, the secretion of FSH, LH and estrogen or androgen is inhibited, resulting in dependence on sex hormones. Sexual diseases (such as prostate cancer, endometriosis, etc.) have a therapeutic effect.

At present, the acetate salt of leuprolide is mainly used clinically, because the performance of leuprolide acetate is more stable at room temperature. Liquid should be discarded. It can be used for the drug castration treatment of endometriosis and uterine fibroids, central precocious puberty, premenopausal breast cancer and prostate cancer, and also for functional uterine bleeding that is contraindicated or ineffective for conventional hormone therapy. It can also be used as a premedication before endometrial resection, which can evenly thin the endometrium, reduce edema, and reduce the difficulty of surgery.


Product detail pictures:

Factory Price For Octreotide - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex detail pictures

Factory Price For Octreotide - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex detail pictures


Related Product Guide:

"Based on domestic market and expand overseas business" is our improvement strategy for Factory Price For Octreotide - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex , The product will supply to all over the world, such as: Manila, Atlanta, Egypt, If you give us a list of products you are interested in, along with makes and models, we can send you quotations. Please email us directly. Our goal is to establish long-term and mutually profitable business relationships with domestic and overseas clients. We look forward to receiving your reply soon.
  • The factory has advanced equipment, experienced staffs and good management level, so product quality had assurance, this cooperation is very relaxed and happy!
    5 Stars By Lulu from Malaysia - 2018.11.02 11:11
    The product classification is very detailed that can be very accurate to meet our demand, a professional wholesaler.
    5 Stars By Victoria from Turkey - 2017.04.08 14:55
    Write your message here and send it to us