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Factory Promotional Xylometazoline Hydrochloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex

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We have now a hugely efficient team to deal with inquiries from buyers. Our goal is "100% client gratification by our solution high-quality, rate & our team service" and take pleasure in a great popularity among clients. With several factories, we will provide a wide assortment of Oxyquinoline Sulphate, 4-Bromophenylacetonitrile, Axitinib, We believe in quality over quantity. Before export of the hair there is strict quality control check during treatment as per international quality standards.
Factory Promotional Xylometazoline Hydrochloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex Detail:

Product Detail

Name  CARBETOCIN
CAS number  37025-55-1
Molecular formula  C45H69N11O12S
Molecular weight  988.17
EINECS Number  253-312-6
Specific rotation  D -69.0° (c = 0.25 in 1M acetic acid)
Boiling point  1477.9±65.0 °C (Predicted)
Density  1.218±0.06 g/cm3(Predicted)
Storage conditions  -15°C
Form  powder

Synonyms

BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN

Biological activity

Carbetocin, an oxytocin (OT) analog, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has a high affinity (Ki=1.17 μM) for the chimeric N-terminus of the oxytocin receptor. Carbetocin has potential for postpartum hemorrhage research. Carbetocin can penetrate the blood-brain barrier and has antidepressant-like activity by activating oxytocin receptors in the CNS.

Function

Carbetocin is a synthetic long-acting oxytocin 8-peptide analog with agonist properties, and its clinical and pharmacological properties are similar to those of naturally occurring oxytocin. Like oxytocin, carbetocin binds to the hormone receptors of uterine smooth muscle, causing rhythmic contractions of the uterus, increasing its frequency and increasing uterine tone on the basis of the contractions of the original. Oxytocin receptor levels in the uterus are low in the non-pregnant state, increase during pregnancy, and peak during labor. Therefore, carbetocin has no effect on the non-pregnant uterus, but has a potent uterine contractile effect on the pregnant uterus and the newly produced uterus.

Change Controls

Changes are controlled according to the procedure. Based on the impact and risk and severity, changes are classified as Major, Minor and Site. Site changes have slight impact on safety and quality of product, and therefore do not need approval and notification to the customer; Minor changes have moderate impact on safety and quality of product, and need to notify the customer; Major changes have higher impact on safety and quality of product, and need approval by the customer.

According to the procedure, change control is started with change application in which change details and rational for the change are described. The evaluation is then performed following the application, which is done by change control relevant departments. Meanwhile, the change control is classified into Major level, General level and Minor level. After appropriate evaluation as well as the classification, all level change control should be approved by QA Manager. The change control is executed after approval according to the action plan. The change control is finally closed after QA confirms the change control has been appropriately implemented. If involving client notification, the client should be notified timely after change control approved


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Factory Promotional Xylometazoline Hydrochloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage  – Gentolex detail pictures


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Our target should be to consolidate and improve the high-quality and repair of current goods, in the meantime regularly produce new solutions to meet unique customers' needs for Factory Promotional Xylometazoline Hydrochloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex , The product will supply to all over the world, such as: Iran, Uruguay, New Delhi, With its rich manufacturing experience, high-quality products, and perfect after-sale service, the company has gained good reputation and has become one of the famous enterprise specialized in manufacturing series.We sincerely hope to establish business relation with you and pursue mutual benefit.
  • We are really happy to find such a manufacturer that ensuring product quality at the same time the price is very cheap.
    5 Stars By Atalanta from El Salvador - 2017.08.15 12:36
    The factory workers have rich industry knowledge and operational experience, we learned a lot in working with them,we are extremely grateful that we can encount a good company has excellent wokers.
    5 Stars By Beatrice from Lithuania - 2018.03.03 13:09
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