• head_banner_01

Hot New Products Low Potassium High Chloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

"Control the standard by the details, show the power by quality". Our business has strived to establish a highly efficient and stable team staff and explored an effective good quality regulate course of action for Nicotinamide Riboside Chloride, Sodium And Chloride, 5-Chloro-2-Bromobenzaldehyde, We're going to continually strive to improve our provider and give the very best high quality products and solutions with aggressive charges. Any inquiry or comment is really appreciated. Please get hold of us freely.
Hot New Products Low Potassium High Chloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex Detail:

Product Detail

Name  CARBETOCIN
CAS number  37025-55-1
Molecular formula  C45H69N11O12S
Molecular weight  988.17
EINECS Number  253-312-6
Specific rotation  D -69.0° (c = 0.25 in 1M acetic acid)
Boiling point  1477.9±65.0 °C (Predicted)
Density  1.218±0.06 g/cm3(Predicted)
Storage conditions  -15°C
Form  powder

Synonyms

BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN

Biological activity

Carbetocin, an oxytocin (OT) analog, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has a high affinity (Ki=1.17 μM) for the chimeric N-terminus of the oxytocin receptor. Carbetocin has potential for postpartum hemorrhage research. Carbetocin can penetrate the blood-brain barrier and has antidepressant-like activity by activating oxytocin receptors in the CNS.

Function

Carbetocin is a synthetic long-acting oxytocin 8-peptide analog with agonist properties, and its clinical and pharmacological properties are similar to those of naturally occurring oxytocin. Like oxytocin, carbetocin binds to the hormone receptors of uterine smooth muscle, causing rhythmic contractions of the uterus, increasing its frequency and increasing uterine tone on the basis of the contractions of the original. Oxytocin receptor levels in the uterus are low in the non-pregnant state, increase during pregnancy, and peak during labor. Therefore, carbetocin has no effect on the non-pregnant uterus, but has a potent uterine contractile effect on the pregnant uterus and the newly produced uterus.

Change Controls

Changes are controlled according to the procedure. Based on the impact and risk and severity, changes are classified as Major, Minor and Site. Site changes have slight impact on safety and quality of product, and therefore do not need approval and notification to the customer; Minor changes have moderate impact on safety and quality of product, and need to notify the customer; Major changes have higher impact on safety and quality of product, and need approval by the customer.

According to the procedure, change control is started with change application in which change details and rational for the change are described. The evaluation is then performed following the application, which is done by change control relevant departments. Meanwhile, the change control is classified into Major level, General level and Minor level. After appropriate evaluation as well as the classification, all level change control should be approved by QA Manager. The change control is executed after approval according to the action plan. The change control is finally closed after QA confirms the change control has been appropriately implemented. If involving client notification, the client should be notified timely after change control approved


Product detail pictures:

Hot New Products Low Potassium High Chloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage  – Gentolex detail pictures


Related Product Guide:

abide by the contract", conforms into the market requirement, joins in the market competition by its good quality also as provides a lot more comprehensive and great company for purchasers to let them turn into huge winner. The pursue from the firm, would be the clients' gratification for Hot New Products Low Potassium High Chloride - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex , The product will supply to all over the world, such as: America, Surabaya, Maldives, Really should any of these items be of interest to you, please let us know. We will be pleased to give you a quotation upon receipt of one's detailed specifications. We've our personal specialist R&D enginners to meet any of the requriements, We look forward to receiving your enquires soon and hope to have the chance to work together with you inside the future. Welcome to take a look at our organization.
  • This is a honest and trustworthy company, technology and equipment are very advanced and the prodduct is very adequate, there is no worry in the suppliment.
    5 Stars By Kim from Italy - 2017.02.14 13:19
    The goods are very perfect and the company sales manager is warmful, we will come to this company to purchase next time.
    5 Stars By Madge from Cyprus - 2018.06.18 19:26
    Write your message here and send it to us