• head_banner_01

Low MOQ for Phenylalanine Amino Acid - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We believe in: Innovation is our soul and spirit. Quality is our life. Customer need is our God for Cesium Chloride, Nirmatrelvir Intermediate Manufacturer, Bepotastine Besilate, Welcome to post your sample and color ring to let us produce according to your specification.Welcome your inquiry! Looking forward to building long-term cooperation with you!
Low MOQ for Phenylalanine Amino Acid - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex Detail:

Product Detail

Name  Linaclotide
CAS number  851199-59-2
Molecular formula  C59H79N15O21S6
Molecular weight  1526.74

Synonyms

Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)

Description

Linaclotide, a synthetic peptide structure containing 14 amino acids, is related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate) Cyclase-C) agonist drugs for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

Chemical Properties

Linaclotide is a white to off-white amorphous powder; slightly soluble in water and aqueous sodium chloride solution (0.9%).

How it works

Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic and endocrine activity. Both linaclotide and its active metabolite can bind to the guanylate cyclase-C (GC-C) receptor on the luminal surface of the small intestinal epithelium. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. The result of GC-C activation is increased intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP can reduce the activity of pain nerve fibers and reduce visceral pain in model animals. Intracellular cGMP can increase the secretion of chloride and bicarbonate in the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which eventually leads to the increase of small intestinal fluid secretion and the speed of small intestinal transit.

FAQ

Do you guarantee safe and secure delivery of products?

Yes, we always use high quality export packaging. We also use specialized hazard packing for dangerous goods and validated cold storage shippers for temperature sensitive items. Specialist packaging and non-standard packing requirements may incur an additional charge.

How about the shipping fees?

The shipping cost depends on the way you choose to get the goods. Express is normally the quickest but also most expensive way. By sea freight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.


Product detail pictures:

Low MOQ for Phenylalanine Amino Acid - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures

Low MOQ for Phenylalanine Amino Acid - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures


Related Product Guide:

We thinks what customers think, the urgency of urgency to act during the interests of a purchaser position of theory, allowing for much better good quality, lower processing costs, prices are extra reasonable, won the new and old buyers the support and affirmation for Low MOQ for Phenylalanine Amino Acid - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex , The product will supply to all over the world, such as: Denmark, UK, Lahore, We've a good reputation for stable quality solutions, well received by customers at home and abroad. Our company would be guided by the idea of "Standing in Domestic Markets, Walking into International Markets". We sincerely hope that we could do business with customers both at home and abroad. We expect sincere cooperation and common development!
  • The company has rich resources, advanced machinery, experienced workers and excellent services, hope you keep improving and perfecting your products and service, wish you better!
    5 Stars By Isabel from Philadelphia - 2017.09.30 16:36
    The supplier cooperation attitude is very good, encountered various problems, always willing to cooperate with us, to us as the real God.
    5 Stars By Juliet from Bangkok - 2018.12.14 15:26
    Write your message here and send it to us