• head_banner_01

Manufacturer for Indacaterol Maleate - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Our mission should be to turn out to be an innovative supplier of high-tech digital and communication devices by furnishing benefit added design and style, world-class manufacturing, and repair capabilities for Desmopressin Acetate Uses, 3 3-Dimethylbutyraldehyde, Sodium Gualenate, We warmly welcome merchants from your home and overseas to contact us and set up business enterprise partnership with us, and we'll do our greatest to serve you.
Manufacturer for Indacaterol Maleate - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex Detail:

Product Detail

Name  Leuprorelin
CAS number  53714-56-0
Molecular formula  C59H84N16O12
Molecular weight  1209.4
EINECS Number  633-395-9
Specific rotation  D25 -31.7° (c = 1 in 1% acetic acid)
Density  1.44±0.1 g/cm3(Predicted)
Storage condition  -15°C
Form  Neat
Acidity coefficient  (pKa) 9.82±0.15 (Predicted)
Water solubility  Soluble in water at 1mg/ml

Synonyms

LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGHORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(HUMAN)

Pharmacological Effect

Leuprolide, goserelin, triprelin, and nafarelin are several drugs commonly used in clinical practice to remove ovaries for the treatment of premenopausal breast cancer and prostate cancer. (referred to as GnRH-a drugs), GnRH-a drugs are similar in structure to GnRH and compete with pituitary GnRH receptors. That is, the gonadotropin secreted by the pituitary decreases, which leads to a significant decrease in the sex hormone secreted by the ovary.

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog, a peptide composed of 9 amino acids. This product can effectively inhibit the function of the pituitary-gonadal system, the resistance to proteolytic enzymes and the affinity to the pituitary GnRH receptor are stronger than GnRH, and the activity of promoting the release of luteinizing hormone (LH) is about 20 times that of GnRH. It also has a stronger inhibitory effect on pituitary-gonad function than GnRH. In the initial stage of treatment, follicle stimulating hormone (FSH), LH, estrogen or androgen may be temporarily increased, and then, due to the decreased responsiveness of the pituitary gland, the secretion of FSH, LH and estrogen or androgen is inhibited, resulting in dependence on sex hormones. Sexual diseases (such as prostate cancer, endometriosis, etc.) have a therapeutic effect.

At present, the acetate salt of leuprolide is mainly used clinically, because the performance of leuprolide acetate is more stable at room temperature. Liquid should be discarded. It can be used for the drug castration treatment of endometriosis and uterine fibroids, central precocious puberty, premenopausal breast cancer and prostate cancer, and also for functional uterine bleeding that is contraindicated or ineffective for conventional hormone therapy. It can also be used as a premedication before endometrial resection, which can evenly thin the endometrium, reduce edema, and reduce the difficulty of surgery.


Product detail pictures:

Manufacturer for Indacaterol Maleate - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex detail pictures

Manufacturer for Indacaterol Maleate - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex detail pictures


Related Product Guide:

Our corporation puts emphasis about the administration, the introduction of talented staff, plus the construction of team building, attempting hard to improve the quality and liability consciousness of team members. Our organization successfully attained IS9001 Certification and European CE Certification of Manufacturer for Indacaterol Maleate - Leuprorelin Acetate Regulates Secretion of Gonadal Hormones – Gentolex , The product will supply to all over the world, such as: Nigeria, Norwegian, Spain, Besides there are also experienced production and management , advanced production equipment to assure our quality and delivery time , our company pursues the principle of good faith, high-quality and high-efficiency. We guarantee that our company will try our best to reduce customer purchase cost, shorten the period of purchase, stable solutions quality, increase customers' satisfaction and achieve win-win situation .
  • As a veteran of this industry, we can say that the company can be a leader in the industry, select them is right.
    5 Stars By Naomi from luzern - 2017.12.31 14:53
    The factory can meet continuously developing economic and market needs, so that their products are widely recognized and trusted, and that's why we chose this company.
    5 Stars By Murray from South Korea - 2018.06.21 17:11
    Write your message here and send it to us