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Massive Selection for (1r,2s)-2-(3,4-Difluorophenyl)Cyclopropanamine (S)-2-Hydroxy-2-Phenylacetate - Daptomycin 103060-53-3 for Infectious Diseases – Gentolex

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Massive Selection for (1r,2s)-2-(3,4-Difluorophenyl)Cyclopropanamine (S)-2-Hydroxy-2-Phenylacetate - Daptomycin 103060-53-3 for Infectious Diseases – Gentolex Detail:

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Name  Daptomycin
CAS number  103060-53-3
Molecular formula  C72H101N17O26
Molecular weight  1620.67
EINECS Number  600-389-2
Melting point  202-204°C
Boiling point  2078.2±65.0 °C (Predicted)
Density  1.45±0.1 g/cm3(Predicted)
Flash point  87℃
Storage conditions  Sealed in dry, Store in freezer, under -20°C
Solubility  Methanol:soluble5mg/mL
Acidity coefficient  (pKa) 4.00±0.10 (Predicted)
Form  powder
Color  colorless to faint yellow

Synonyms

N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)

Description

The antibiotic daptomycin is a cyclic lipopeptide antibiotic with a new structure extracted from the fermentation broth of Streptomyces (S. reseosporus), which hinders the biosynthesis of bacterial cell wall peptidoglycan by disturbing the transport of amino acids in the cell membrane. Altering the properties of the cytoplasmic membrane can disrupt bacterial membrane function in multiple ways and rapidly kill Gram-positive bacteria. In addition to its ability to act on most clinically relevant Gram-positive bacteria, daptomycin is more important for isolated strains that have shown resistance to methicillin, vancomycin, and linezolid in vitro. It has potent activity, and this property has very important clinical implications for critically ill infected patients. Eosinophilic pneumonia is a rare and very serious disease with symptoms including fever, cough, shortness of breath, and difficulty breathing.

Antibacterial Effect

Daptomycin has good bacteriostatic activity against various antibiotic-resistant bacteria, such as MIC=0.06-0.5 μg/ml for methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant Staphylococcus aureus (MRSA). MIC=0.0625~1μg/ml for bacteria, MIC=0.12~0.5μg/ml for oxacillin-resistant Staphylococcus epidermidis, MIC=2.5μg/ml for enterococcus highly resistant to aminoglycoside antibiotics, MIC=2.5μg/ml for GmrBIa -The MIC of Enterococcus is 0.5~1μg/ml, and the MIC of Enterococcus resistant to glycopeptide antibiotics is 1~2μg/ml.


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Massive Selection for (1r,2s)-2-(3,4-Difluorophenyl)Cyclopropanamine (S)-2-Hydroxy-2-Phenylacetate - Daptomycin 103060-53-3 for Infectious Diseases  – Gentolex detail pictures

Massive Selection for (1r,2s)-2-(3,4-Difluorophenyl)Cyclopropanamine (S)-2-Hydroxy-2-Phenylacetate - Daptomycin 103060-53-3 for Infectious Diseases  – Gentolex detail pictures

Massive Selection for (1r,2s)-2-(3,4-Difluorophenyl)Cyclopropanamine (S)-2-Hydroxy-2-Phenylacetate - Daptomycin 103060-53-3 for Infectious Diseases  – Gentolex detail pictures


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Using a complete scientific top quality management program, great high-quality and fantastic religion, we win great track record and occupied this area for Massive Selection for (1r,2s)-2-(3,4-Difluorophenyl)Cyclopropanamine (S)-2-Hydroxy-2-Phenylacetate - Daptomycin 103060-53-3 for Infectious Diseases – Gentolex , The product will supply to all over the world, such as: Malaysia, Libya, Ethiopia, We only supply quality products and we believe this is the only way to keep business continue. We can supply custom service too such as Logo, custom size, or custom products etc that can according to customer's requirement.
  • The factory technical staff gave us a lot of good advice in the cooperation process, this is very good, we are very grateful.
    5 Stars By Mike from Romania - 2017.01.28 19:59
    Speaking of this cooperation with the Chinese manufacturer, I just want to say"well dodne", we are very satisfied.
    5 Stars By Diana from Houston - 2018.07.27 12:26
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