Orlistat 96829-58-2 Reducing Absorption of Sietary Fat, Resulting in Weight Loss

Properties

White crystalline powder, almost insoluble in water, easily soluble in chloroform, extremely soluble in methanol and ethanol, easy to pyrolyze, melting point is 40℃～42℃. Its molecule is a diastereomer containing four chiral centers, at a wavelength of 529nm, its ethanol solution has negative optical rotation.

Mode of Action

Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor, which inactivates the above two enzymes by forming a covalent bond with the active serine site of lipase in the stomach and small intestine. Inactivated enzymes cannot break down fat in food into free fatty acids and Chemicalbook glycerol that can be absorbed by the body, thereby reducing fat intake and reducing weight. In addition, some studies have found that orlistat inhibits intestinal absorption of cholesterol by inhibiting niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).

Indications

This product in combination with a mild hypocaloric diet is indicated for the long-term treatment of obese and overweight individuals, including those with established risk factors associated with obesity. This product has long-term weight control (weight loss, weight maintenance and prevention of rebound) efficacy. Taking orlistat can reduce obesity-related risk factors and the incidence of other obesity-related diseases, including hypercholesterolemia, type 2 diabetes, impaired glucose tolerance, hyperinsulinemia, hypertension, and organ reduction fat content.

Medicine Interactions

Can reduce the absorption of vitamins A, D and E. It can be supplemented with this product at the same time. If you are taking preparations containing vitamins A, D and E (such as some multivitamins), you should take this product 2 hours after taking this product or at bedtime. People with type 2 diabetes may need to reduce the dose of oral hypoglycemic agents (eg, sulfonylureas). Co-administration with cyclosporine can result in a decrease in plasma concentrations of the latter. Concomitant use of amiodarone may result in decreased absorption of the latter and reduced efficacy.