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Personlized Products Chloride Shift - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex

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Personlized Products Chloride Shift - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Detail:

Product Detail

Name  N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
CAS number  14636-12-5
Molecular formula  C52H74N16O15S2
Molecular weight  1227.37
EINECS Number  238-680-8
Boiling point  1824.0±65.0 °C (Predicted)
Density  1.46±0.1 g/cm3(Predicted)
Storage conditions  Keep in dark place, Inert atmosphere, Store in freezer, under -15°C.
Acidity coefficient  (pKa) 9.90±0.15 (Predicted)

Synonyms

[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.

Description

Terlipressin, whose chemical name is triglycyllysine vasopressin, is a new synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. It is acted by aminopeptidase in vivo to slowly “release” the active lysine vasopressin after removing the three glycyl residues at its N-terminus. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.

The pharmacological effect of terlipressin is to contract splanchnic vascular smooth muscle and reduce splanchnic blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal blood flow and portal pressure. On the other hand, it can also reduce plasma The effect of renin concentration, thereby increasing renal blood flow, improving renal function and increasing urine output in patients with hepatorenal syndrome. Terlipressin is currently the only drug that can improve the survival rate of patients with esophageal variceal hemorrhage. It was mainly used in the clinical treatment of variceal hemorrhage. In addition, terlipressin has also been successfully used in the liver and kidney. In general, it is likely to play a beneficial role in coexisting refractory shock and cardiopulmonary resuscitation. Compared with vasopressin, it has a long-lasting effect, does not cause dangerous complications, including fibrinolysis and serious complications in the cardiovascular system, and is simple to use (intravenous injection), which is more suitable for acute and critical care. Rescue and treatment of critically ill patients.


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Personlized Products Chloride Shift - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

Personlized Products Chloride Shift - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

Personlized Products Chloride Shift - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures


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To become the stage of realizing dreams of our employees! To build a happier, more united and extra professional workforce! To reach a mutual advantage of our prospects, suppliers, the society and ourselves for Personlized Products Chloride Shift - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex , The product will supply to all over the world, such as: Sudan, Libya, Oman, With the growing of the company, now our products sold and served at more than 15 countries around the world,such as Europe,North America,Middle-east,South America,Southern Asia and so on. As we bear in our mind that innovation is essential to our growth, new product development is constantly.Besides, Our flexible and efficient operation strategies,High quality products and competitive prices are exactly what our customers are looking for. Also a considerable service brings us good credit reputation.
  • We are old friends, the company's product quality has been always very good and this time the price is also very cheap.
    5 Stars By Alice from Croatia - 2017.07.07 13:00
    As an international trading company, we have numerous partners, but about your company, I just want to say, you are really good, wide range, good quality, reasonable prices, warm and thoughtful service, advanced technology and equipment and workers have professional training, feedback and product update is timely, in short, this is a very pleasant cooperation, and we look forward to the next cooperation!
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