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Professional Design 5-Bromo-2-Chlorobenzaldehyde - Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 – Gentolex

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Professional Design 5-Bromo-2-Chlorobenzaldehyde - Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 – Gentolex Detail:

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CAS 204656-20-2 Molecular Formula C172H265N43O51  
Molecular Weight 3751.20 Appearance White
Storage Condition Light resistance, 2-8 degree Package Aluminum foil bag/vial
Purity ≥98% Transportation Cold Chain and cool storage delivery

Ingredients of Liraglutide

Application

Type 2 diabetes

Liraglutide improves control of blood glucose. It reduces meal-related hyperglycemia (for 24 hours after administration) by increasing insulin secretion (only) when required by increasing glucose levels, delaying gastric emptying, and suppressing prandial glucagon secretion.
It is suitable for patients whose blood sugar is still poorly controlled after the maximum tolerated dose of metformin or sulfonylureas alone. It is used in combination with metformin or sulfonylureas.
It acts in a glucose-dependent manner, meaning it will stimulate insulin secretion only when blood glucose levels are higher than normal, preventing “overshoot”. Consequently, it shows negligible risk of hypoglycemia.
It has the potential for inhibiting apoptosis and stimulating regeneration of beta cells (seen in animal studies).
It decreases appetite and inhibits body weight gain, as shown in a head-to-head study versus glimepiride.

Pharmacological Action

Liraglutide is a GLP-1 analog with 97% sequence homology to human GLP-1, which can bind to and activate the GLP-1 receptor. The GLP-1 receptor is the target of native GLP-1, an endogenous incretin hormone that promotes glucose concentration-dependent insulin secretion from pancreatic β cells. Unlike native GLP-1, the pharmacokinetic and pharmacodynamic profiles of liraglutide in humans are suitable for a once-daily dosing regimen. After subcutaneous injection, its mechanism of prolonged action includes: self-association that slows absorption; binding to albumin; Higher enzyme stability and thus longer plasma half-life.

The activity of liraglutide is mediated by its specific interaction with the GLP-1 receptor, resulting in an increase in cyclic adenosine monophosphate (cAMP). Liraglutide stimulates insulin secretion in a glucose concentration-dependent manner, while reducing excess glucagon secretion in a glucose concentration-dependent manner.

Therefore, when blood glucose rises, insulin secretion is stimulated, while glucagon secretion is inhibited. In contrast, liraglutide reduces insulin secretion during hypoglycemia without affecting glucagon secretion. The hypoglycemic mechanism of liraglutide also includes a slight prolongation of gastric emptying time. Liraglutide reduces body weight and body fat mass by reducing hunger and energy intake.


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Professional Design 5-Bromo-2-Chlorobenzaldehyde - Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 – Gentolex detail pictures


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Our concentrate on is always to consolidate and enhance the excellent and service of present solutions, in the meantime regularly develop new products to meet distinctive customers' demands for Professional Design 5-Bromo-2-Chlorobenzaldehyde - Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 – Gentolex , The product will supply to all over the world, such as: Portugal, Amsterdam, Chicago, As an experienced factory we also accept customized order and make it same as your picture or sample specifying specification and customer design packing. The main goal of the company is to live a satisfactory memory to all the customers, and establish a long term win-win business relationship. For more information, please contact us. And It is our great pleasure if you like to have a personally meeting in our office.
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