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Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Featured Image
  • Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex
  • Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex
  • Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex

Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex

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Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Detail:

Product Detail

Name  N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
CAS number  14636-12-5
Molecular formula  C52H74N16O15S2
Molecular weight  1227.37
EINECS Number  238-680-8
Boiling point  1824.0±65.0 °C (Predicted)
Density  1.46±0.1 g/cm3(Predicted)
Storage conditions  Keep in dark place, Inert atmosphere, Store in freezer, under -15°C.
Acidity coefficient  (pKa) 9.90±0.15 (Predicted)

Synonyms

[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.

Description

Terlipressin, whose chemical name is triglycyllysine vasopressin, is a new synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. It is acted by aminopeptidase in vivo to slowly “release” the active lysine vasopressin after removing the three glycyl residues at its N-terminus. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.

The pharmacological effect of terlipressin is to contract splanchnic vascular smooth muscle and reduce splanchnic blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal blood flow and portal pressure. On the other hand, it can also reduce plasma The effect of renin concentration, thereby increasing renal blood flow, improving renal function and increasing urine output in patients with hepatorenal syndrome. Terlipressin is currently the only drug that can improve the survival rate of patients with esophageal variceal hemorrhage. It was mainly used in the clinical treatment of variceal hemorrhage. In addition, terlipressin has also been successfully used in the liver and kidney. In general, it is likely to play a beneficial role in coexisting refractory shock and cardiopulmonary resuscitation. Compared with vasopressin, it has a long-lasting effect, does not cause dangerous complications, including fibrinolysis and serious complications in the cardiovascular system, and is simple to use (intravenous injection), which is more suitable for acute and critical care. Rescue and treatment of critically ill patients.

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Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex detail pictures

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Our growth depends on the superior equipment ,exceptional talents and continuously strengthened technology forces for Professional Design 5-Bromo-2-Chlorobenzaldehyde - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex , The product will supply to all over the world, such as: Sevilla, Portugal, Adelaide, Our products are widely sold to Europe, USA, Russia, UK, France, Australia, Middle East, South America, Africa, and Southeast Asia, etc. Our products are highly recognized by our customers from all around the world. And our company is committed to continually improving effectiveness of our management system to maximize customer satisfaction. We sincerely hope to make progress with our customers and create a win-win future together. Welcome to join us for business!
    • The manufacturer gave us a big discount under the premise of ensuring the quality of products, thank you very much, we will select this company again.
    5 Stars By Lauren from Albania - 2017.02.14 13:19
    This is the first business after our company establish, products and services are very satisfying, we have a good start, we hope to cooperate continuous in the future!
    5 Stars By Lindsay from Kenya - 2018.09.21 11:01
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