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Super Purchasing for Cetylpyridinium Chloride - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex

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Super Purchasing for Cetylpyridinium Chloride - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex Detail:

Product Detail

Name  Linaclotide
CAS number  851199-59-2
Molecular formula  C59H79N15O21S6
Molecular weight  1526.74

Synonyms

Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)

Description

Linaclotide, a synthetic peptide structure containing 14 amino acids, is related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate) Cyclase-C) agonist drugs for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

Chemical Properties

Linaclotide is a white to off-white amorphous powder; slightly soluble in water and aqueous sodium chloride solution (0.9%).

How it works

Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic and endocrine activity. Both linaclotide and its active metabolite can bind to the guanylate cyclase-C (GC-C) receptor on the luminal surface of the small intestinal epithelium. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. The result of GC-C activation is increased intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP can reduce the activity of pain nerve fibers and reduce visceral pain in model animals. Intracellular cGMP can increase the secretion of chloride and bicarbonate in the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which eventually leads to the increase of small intestinal fluid secretion and the speed of small intestinal transit.

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Do you guarantee safe and secure delivery of products?

Yes, we always use high quality export packaging. We also use specialized hazard packing for dangerous goods and validated cold storage shippers for temperature sensitive items. Specialist packaging and non-standard packing requirements may incur an additional charge.

How about the shipping fees?

The shipping cost depends on the way you choose to get the goods. Express is normally the quickest but also most expensive way. By sea freight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.


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Super Purchasing for Cetylpyridinium Chloride - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures

Super Purchasing for Cetylpyridinium Chloride - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures


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We thinks what buyers think, the urgency of urgency to act during the interests of a purchaser position of theory, allowing for much better high-quality, reduced processing costs, charges are more reasonable, won the new and outdated consumers the support and affirmation for Super Purchasing for Cetylpyridinium Chloride - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex , The product will supply to all over the world, such as: India, Mozambique, Austria, Customer satisfaction is our goal. We are looking forward to cooperating with you and providing our best services for you. We warmly welcome you to contact us and please feel free to contact us. Browse our online showroom to see what we can do for you. And then E-mail us your specifications or inquiries today.
  • The company can think what our think, the urgency of urgency to act in the interests of our position, can be said this is a responsible company, we had a happy cooperation!
    5 Stars By Alexandra from Iran - 2018.11.06 10:04
    This supplier offers high quality but low price products, it is really a nice manufacturer and business partner.
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