• head_banner_01

Trending Products Hexenyl Acetate - Caspofungin for Antifungal Infections – Gentolex

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We support our prospective buyers with ideal top quality merchandise and superior level provider. Becoming the specialist manufacturer in this sector, we have now attained abundant practical expertise in producing and managing for Sodium Chloride For Wounds, Pharmaceutical Raw Materials, Lead 2 Acetate, We can easily offer you by far the most aggressive prices and good quality, because we've been much additional Specialist! So please will not hesitate to call us.
Trending Products Hexenyl Acetate - Caspofungin for Antifungal Infections – Gentolex Detail:

Product Detail

Name  Caspofungin
CAS number  162808-62-0
Molecular formula  C52H88N10O15
Molecular weight  1093.31
EINECS Number  1806241-263-5
Boiling point  1408.1±65.0 °C (Predicted)
Density  1.36±0.1 g/cm3(Predicted)
Acidity coefficient  (pKa) 9.86±0.26 (Predicted)

Synonyms

CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650

Chemical Properties

Caspofungin was the first echinocandin approved for the treatment of invasive fungal infections. In vitro and in vivo experiments confirmed that caspofungin has good antibacterial activity against important opportunistic pathogens-Candida and Aspergillus. Caspofungin can rupture the cell wall by inhibiting the synthesis of 1,3-β-glucan. Clinically, caspofungin has a good effect on the treatment of various candidiasis and aspergillosis.

Effect

(1,3)-D-glucan synthase is a key component of fungal cell wall synthesis, and caspofungin can exert an antifungal effect by non-competitively inhibiting this enzyme. After intravenous administration, the plasma drug concentration drops rapidly due to tissue distribution, followed by a gradual rerelease of the drug from the tissue. Metabolism of caspofungin increased with increasing dose and was dose-related in the time to steady state with multiple doses. Therefore, in order to achieve effective therapeutic levels and avoid drug accumulation, a first loading dose should be administered followed by a maintenance dose. When using cytochrome p4503A4 inducers at the same time, such as rifampicin, carbamazepine, dexamethasone, phenytoin, etc., it is recommended to increase the maintenance dose of caspofungin.

Indications

FDA-approved indications for caspofungin include: 1. Fever with neutropenia: defined as: fever >38°C with absolute neutrophil count (ANC) ≤500/ml, or with ANC ≤1000/ml and it is predicted that it can be reduced to below 500/ml. According to the recommendation of the Infectious Diseases Society of America (IDSA), although patients with persistent fever and neutropenia have been treated with broad-spectrum antibiotics, high-risk patients are still recommended to use empiric antifungal therapy, including caspofungin and other antifungal drugs. . 2. Invasive candidiasis: IDSA recommends echinocandins (such as caspofungin) as the drug of choice for candidemia. It can also be used to treat intra-abdominal abscesses, peritonitis and chest infections caused by Candida infection. 3. Esophageal candidiasis: Caspofungin can be used to treat esophageal candidiasis in patients with refractory or intolerance to other therapies. Several studies have found that the therapeutic effect of caspofungin is comparable to that of fluconazole. 4. Invasive aspergillosis: Caspofungin has been approved for the treatment of invasive aspergillosis in patients with intolerance, resistance, and ineffectiveness of the main antifungal drug, voriconazole. However, echinocandin is not recommended as first-line therapy.


Product detail pictures:

Trending Products Hexenyl Acetate - Caspofungin for Antifungal Infections – Gentolex detail pictures

Trending Products Hexenyl Acetate - Caspofungin for Antifungal Infections – Gentolex detail pictures


Related Product Guide:

Sticking for the principle of "Super Quality, Satisfactory service" ,We have been striving for being a superb small business partner of you for Trending Products Hexenyl Acetate - Caspofungin for Antifungal Infections – Gentolex , The product will supply to all over the world, such as: Belarus, United States, Mauritania, At present our sales network is growing continually, improving service quality to meet customer's demand. If you are interested in any products , please contact us at anytime. We are looking forward to forming successful business relationships with you in near future.
  • The company's products very well, we have purchased and cooperated many times, fair price and assured quality, in short, this is a trustworthy company!
    5 Stars By David from Malaysia - 2018.06.09 12:42
    The goods are very perfect and the company sales manager is warmful, we will come to this company to purchase next time.
    5 Stars By Riva from British - 2017.08.21 14:13
    Write your message here and send it to us