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Wholesale Dealers of Essential Amino Acids - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex

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Wholesale Dealers of Essential Amino Acids - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex Detail:

Product Detail

Name  Linaclotide
CAS number  851199-59-2
Molecular formula  C59H79N15O21S6
Molecular weight  1526.74

Synonyms

Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)

Description

Linaclotide, a synthetic peptide structure containing 14 amino acids, is related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate) Cyclase-C) agonist drugs for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

Chemical Properties

Linaclotide is a white to off-white amorphous powder; slightly soluble in water and aqueous sodium chloride solution (0.9%).

How it works

Linaclotide is a guanylate cyclase-C receptor agonist (GCCA) with both visceral analgesic and endocrine activity. Both linaclotide and its active metabolite can bind to the guanylate cyclase-C (GC-C) receptor on the luminal surface of the small intestinal epithelium. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. The result of GC-C activation is increased intracellular and extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP can reduce the activity of pain nerve fibers and reduce visceral pain in model animals. Intracellular cGMP can increase the secretion of chloride and bicarbonate in the small intestine by activating CFTR (cystic fibrosis transmembrane conductance regulator), which eventually leads to the increase of small intestinal fluid secretion and the speed of small intestinal transit.

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Do you guarantee safe and secure delivery of products?

Yes, we always use high quality export packaging. We also use specialized hazard packing for dangerous goods and validated cold storage shippers for temperature sensitive items. Specialist packaging and non-standard packing requirements may incur an additional charge.

How about the shipping fees?

The shipping cost depends on the way you choose to get the goods. Express is normally the quickest but also most expensive way. By sea freight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.


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Wholesale Dealers of Essential Amino Acids - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures

Wholesale Dealers of Essential Amino Acids - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex detail pictures


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We're convinced that with joint endeavours, the business between us will bring us mutual benefits. We are able to guarantee you products high quality and competitive value for Wholesale Dealers of Essential Amino Acids - Linaclotide for Gastrointestinal Disorders 851199-59-2 – Gentolex , The product will supply to all over the world, such as: Paris, Kenya, Jersey, Our professional engineering group will always be ready to serve you for consultation and feedback. We are able to also offer you with absolutely free samples to meet your requirements. Finest efforts will likely be produced to give you the ideal service and goods. For anyone who is thinking about our company and merchandise, please contact us by sending us emails or contact us quickly. As a way to know our merchandise and firm. lot more, you can come to our factory to find out it. We'll always welcome guests from all over the world to our business to build company relations with us. Please feel free to get in touch with us for business and we believe we are going to share the top trading practical experience with all our merchants.
  • The company comply with the contract strict, a very reputable manufacturers, worthy a long-term cooperation.
    5 Stars By Marguerite from Panama - 2018.11.11 19:52
    The goods are very perfect and the company sales manager is warmful, we will come to this company to purchase next time.
    5 Stars By Susan from Jeddah - 2018.06.09 12:42
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