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Wholesale Na Stearate - Paclitaxel 33069-62-4 Anti-tumor Botanical Medicine for Ovarian Cancer, Breast Cancer – Gentolex

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Wholesale Na Stearate - Paclitaxel 33069-62-4 Anti-tumor Botanical Medicine for Ovarian Cancer, Breast Cancer – Gentolex Detail:

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Name  Leuprorelin
CAS number  53714-56-0
Molecular formula  C59H84N16O12
Molecular weight  1209.4
EINECS Number  633-395-9
Specific rotation  D25 -31.7° (c = 1 in 1% acetic acid)
Density  1.44±0.1 g/cm3(Predicted)
Storage condition  -15°C
Form  Neat
Acidity coefficient  (pKa) 9.82±0.15 (Predicted)
Water solubility  Soluble in water at 1mg/ml

Synonyms

LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGHORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(HUMAN)

Pharmacological Effect

Leuprolide, goserelin, triprelin, and nafarelin are several drugs commonly used in clinical practice to remove ovaries for the treatment of premenopausal breast cancer and prostate cancer. (referred to as GnRH-a drugs), GnRH-a drugs are similar in structure to GnRH and compete with pituitary GnRH receptors. That is, the gonadotropin secreted by the pituitary decreases, which leads to a significant decrease in the sex hormone secreted by the ovary.

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog, a peptide composed of 9 amino acids. This product can effectively inhibit the function of the pituitary-gonadal system, the resistance to proteolytic enzymes and the affinity to the pituitary GnRH receptor are stronger than GnRH, and the activity of promoting the release of luteinizing hormone (LH) is about 20 times that of GnRH. It also has a stronger inhibitory effect on pituitary-gonad function than GnRH. In the initial stage of treatment, follicle stimulating hormone (FSH), LH, estrogen or androgen may be temporarily increased, and then, due to the decreased responsiveness of the pituitary gland, the secretion of FSH, LH and estrogen or androgen is inhibited, resulting in dependence on sex hormones. Sexual diseases (such as prostate cancer, endometriosis, etc.) have a therapeutic effect.

At present, the acetate salt of leuprolide is mainly used clinically, because the performance of leuprolide acetate is more stable at room temperature. Liquid should be discarded. It can be used for the drug castration treatment of endometriosis and uterine fibroids, central precocious puberty, premenopausal breast cancer and prostate cancer, and also for functional uterine bleeding that is contraindicated or ineffective for conventional hormone therapy. It can also be used as a premedication before endometrial resection, which can evenly thin the endometrium, reduce edema, and reduce the difficulty of surgery.


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Wholesale Na Stearate - Paclitaxel 33069-62-4 Anti-tumor Botanical Medicine for Ovarian Cancer, Breast Cancer – Gentolex detail pictures

Wholesale Na Stearate - Paclitaxel 33069-62-4 Anti-tumor Botanical Medicine for Ovarian Cancer, Breast Cancer – Gentolex detail pictures


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Bear "Customer 1st, Good quality first" in mind, we work closely with our prospects and supply them with efficient and professional services for Wholesale Na Stearate - Paclitaxel 33069-62-4 Anti-tumor Botanical Medicine for Ovarian Cancer, Breast Cancer – Gentolex , The product will supply to all over the world, such as: Boston, Romania, Sweden, The quality of our merchandise is equal to OEM's quality, because our core parts are the same with OEM supplier. The above items have passed professional certification, and we not only can produce OEM-standard items but we also accept Customized Merchandise order.
  • The company can think what our think, the urgency of urgency to act in the interests of our position, can be said this is a responsible company, we had a happy cooperation!
    5 Stars By Martin Tesch from Poland - 2018.02.12 14:52
    High production efficiency and good product quality, fast delivery and completed after-sale protection, a right choice, a best choice.
    5 Stars By Louise from Miami - 2017.04.28 15:45
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